BDBM747274 14 (2-(4-(2-(6-Methylpyridin-2-yl)- 6,7-dihydro-5H-pyrrolo[1,2- alimidazol-3-yl)pyridin-2-yl)-4,6- dihydropyrrolo[3,4-d]imidazol- 5(1H)-yl)(morpholin-4-yl)ketone::US20250179094, Compound 14::US20250215017, Compound 33

SMILES Cc1cccc(-c2nc3n(c2-c2ccnc(-c4nc5c([nH]4)CN(C(=O)N4CCOCC4)C5)c2)CCC3)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 747274   

TargetTGF-beta receptor type-1(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandPNGBDBM747274(14 (2-(4-(2-(6-Methylpyridin-2-yl)- 6,7-dihydro-5H...)
Affinity DataIC50: 1.70nMAssay Description:The principle of the activity assay was that TGFβR1 phosphorylates the substrate TGFβR1tide, consuming ATP in the process. This experiment employed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandPNGBDBM747274(14 (2-(4-(2-(6-Methylpyridin-2-yl)- 6,7-dihydro-5H...)
Affinity DataIC50: 7.90nMAssay Description:The principle of the activity assay was that TGFβR1 phosphorylates the substrate TGFβR1tide, consuming ATP in the process. This experiment employed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandPNGBDBM747274(14 (2-(4-(2-(6-Methylpyridin-2-yl)- 6,7-dihydro-5H...)
Affinity DataIC50: 7.90nMAssay Description:The principle of the activity assay was that TGFβR1 phosphorylates the substrate TGFβR1tide, consuming ATP in the process. This experiment employed t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent