BDBM747587 US12325697, Compound AII-9

SMILES Cn1cnnc1-c1cc(F)cc(F)c1-c1cc(C2CC2)nc(N2Cc3ccc(CNCC4(O)CCC4)cc3C2=O)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 747587   

LigandPNGBDBM747587(US12325697, Compound AII-9)
Affinity DataIC50: 200nMAssay Description:Fluorescein-BODIPY labeled UBED2D(C85K)-Ub was prepared by conjugating ubiquitin (Ub) labeled at its N-terminus with Fluorescein-BODIPY maleimide (Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C [47-435](Human)
Nimbus Clio

US Patent
LigandPNGBDBM747587(US12325697, Compound AII-9)
Affinity DataIC50: 200nMAssay Description:Recombinant human c-Cbl (aa 47-435) was expressed in E. coli, purified and biotinylated in vitro. The protein was diluted to 12 nM in freshly prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/4/2025
Entry Details
US Patent