BDBM748308 4-((2S,5R)-5-ethyl-2-methyl-4-((R)-1-(4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)-2-methyl-1-(((S)-tetrahydrofuran-2-yl)methyl)-1H-[1,2,4]triazolo[3,4-b]purine::US20250186450, Example 15

SMILES CC[C@@H]1CN(C2Nc3nncn3C3C2N=C(C)N3C[C@@H]2CCCO2)[C@@H](C)CN1[C@@H](C)c1ccc(C(F)(F)F)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 748308   

TargetDiacylglycerol kinase zeta(Human)
Incyte

US Patent
LigandPNGBDBM748308(4-((2S,5R)-5-ethyl-2-methyl-4-((R)-1-(4-(trifluoro...)
Affinity DataIC50: 20nMAssay Description:The DGKα and DGKζ biochemical reactions were performed using His-tagged human recombinant enzymes (Signal Chem, DGKα, #D21-10BH; DGKζ, #D30-10H)) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetDiacylglycerol kinase alpha(Human)
Incyte

US Patent
LigandPNGBDBM748308(4-((2S,5R)-5-ethyl-2-methyl-4-((R)-1-(4-(trifluoro...)
Affinity DataIC50: 20nMAssay Description:The DGKα and DGKζ biochemical reactions were performed using His-tagged human recombinant enzymes (Signal Chem, DGKα, #D21-10BH; DGKζ, #D30-10H)) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent