BDBM748313 4-((2S,5R)-4-((R)-1-(4-chlorophenyl)propyl)-2,5-dimethylpiperazin-1-yl)-1-(((S)-tetrahydrofuran-2-yl)methyl)-1H-[1,2,4]triazolo[3,4-b]purine::US20250186450, Example 20

SMILES CC[C@@H](c1ccc(Cl)cc1)N1C[C@H](C)N(C2Nc3nncn3C3C2N=CN3C[C@@H]2CCCO2)C[C@H]1C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 748313   

TargetDiacylglycerol kinase alpha(Human)
Incyte

US Patent
LigandPNGBDBM748313(4-((2S,5R)-4-((R)-1-(4-chlorophenyl)propyl)-2,5-di...)
Affinity DataIC50: 20nMAssay Description:The DGKα and DGKζ biochemical reactions were performed using His-tagged human recombinant enzymes (Signal Chem, DGKα, #D21-10BH; DGKζ, #D30-10H)) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetDiacylglycerol kinase zeta(Human)
Incyte

US Patent
LigandPNGBDBM748313(4-((2S,5R)-4-((R)-1-(4-chlorophenyl)propyl)-2,5-di...)
Affinity DataIC50: 110nMAssay Description:The DGKα and DGKζ biochemical reactions were performed using His-tagged human recombinant enzymes (Signal Chem, DGKα, #D21-10BH; DGKζ, #D30-10H)) and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent