BDBM748781 (S)-3-amino-N-(5,5-difluoropiperidin- 3-yl)-6-(5-fluoro-2-(1-(2,2,2-trifluoroethyl)- 1H-pyrazol-4-yl)pyridin-4-yl)pyrazine- 2-carboxamide::US20250188059, Example 4

SMILES Nc3ncc(c2cc(c1cnn(CC(F)(F)F)c1)ncc2F)nc3C(=O)NC4CNCC(F)(F)C4

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 748781   

TargetSerine/threonine-protein kinase Chk2(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748781((S)-3-amino-N-(5,5-difluoropiperidin- 3-yl)-6-(5-f...)
Affinity DataIC50: 55nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748781((S)-3-amino-N-(5,5-difluoropiperidin- 3-yl)-6-(5-f...)
Affinity DataIC50: 1.00E+3nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent