BDBM748805 3-amino-6-(3-(1-(2-hydroxy-2- methylpropyl)-1H-pyrazol-4- yl)phenyl)-N-((3R,4R)-4- hydroxypiperidin-3-yl)pyrazine-2- carboxamide::US20250188059, Example 28

SMILES CC(C)(O)Cn1cc(-c2cccc(-c3cnc(N)c(C(=O)N[C@@H]4CNCC[C@H]4O)n3)c2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 748805   

TargetSerine/threonine-protein kinase Chk2(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748805(3-amino-6-(3-(1-(2-hydroxy-2- methylpropyl)-1H-pyr...)
Affinity DataIC50: 10nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748805(3-amino-6-(3-(1-(2-hydroxy-2- methylpropyl)-1H-pyr...)
Affinity DataIC50: 1.00E+3nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent