BDBM748812 3-amino-6-(2-fluoro-5-(1-(2-hydroxy- 2-methylpropyl)-1H-pyrazol-4- yl)phenyl)-N-((3S,5S)-5- fluoropiperidin-3-yl)pyrazine-2- carboxamide::US20250188059, Example 35

SMILES CC(C)(O)Cn1cc(-c2ccc(F)c(-c3cnc(N)c(C(=O)NC4CNC[C@@H](F)C4)n3)c2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 748812   

TargetSerine/threonine-protein kinase Chk2(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748812(3-amino-6-(2-fluoro-5-(1-(2-hydroxy- 2-methylpropy...)
Affinity DataIC50: 55nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748812(3-amino-6-(2-fluoro-5-(1-(2-hydroxy- 2-methylpropy...)
Affinity DataIC50: 1.00E+3nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent