BDBM748814 3-amino-N-((3S,5S)-5- fluoropiperidin-3-yl)-6-(5-(1-(2- hydroxy-2-methylpropyl)-1H-pyrazol- 4-yl)-2-methylphenyl) pyrazine-2-carboxamide::US20250188059, Example 37

SMILES Cc1ccc(-c2cnn(CC(C)(C)O)c2)cc1-c1cnc(N)c(C(=O)NC2CNC[C@@H](F)C2)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 748814   

TargetSerine/threonine-protein kinase Chk2(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748814(3-amino-N-((3S,5S)-5- fluoropiperidin-3-yl)-6-(5-(...)
Affinity DataIC50: 55nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748814(3-amino-N-((3S,5S)-5- fluoropiperidin-3-yl)-6-(5-(...)
Affinity DataIC50: 1.00E+3nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent