BDBM748822 3-amino-6-(3-(5,5-dimethyl-5,6-dihydro- 4H-pyrrolo[1,2-b]pyrazol-3-yl)phenyl)-N- ((3S,5S)-5-fluoropiperidin-3-yl)pyrazine-2- carboxamide::US20250188059, Example 45

SMILES CC1(C)Cc2c(-c3cccc(-c4cnc(N)c(C(=O)N[C@@H]5CNC[C@@H](F)C5)n4)c3)cnn2C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 748822   

TargetSerine/threonine-protein kinase Chk2(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748822(3-amino-6-(3-(5,5-dimethyl-5,6-dihydro- 4H-pyrrolo...)
Affinity DataIC50: 10nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
Arum Therapeutics

US Patent
LigandPNGBDBM748822(3-amino-6-(3-(5,5-dimethyl-5,6-dihydro- 4H-pyrrolo...)
Affinity DataIC50: 550nMAssay Description:The compounds of Examples 1 to 66 were diluted at various concentrations and transferred to a 384-well plate by 5 μl, and 10 μl of a mixed solution (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent