BDBM748860 4,4-difluoro-2-(1-methylpyrazol-4-yl)-N-[4-[3-(2-pyridyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-2-pyridyl]butanamide::US20250188075, Example 19

SMILES Cn1cc(C(CC(F)F)C(=O)Nc2cc(-c3[nH]c4cccnc4c3-c3ccccn3)ccn2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 748860   

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM748860(4,4-difluoro-2-(1-methylpyrazol-4-yl)-N-[4-[3-(2-p...)
Affinity DataIC50: 6.82nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a white 1536-well microtiter plate (Greiner Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
The Broad Institute

US Patent
LigandPNGBDBM748860(4,4-difluoro-2-(1-methylpyrazol-4-yl)-N-[4-[3-(2-p...)
Affinity DataIC50: 13.9nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a white 1536-well microtiter plate (Greiner Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetCasein kinase I isoform gamma-3(Human)
The Broad Institute

US Patent
LigandPNGBDBM748860(4,4-difluoro-2-(1-methylpyrazol-4-yl)-N-[4-[3-(2-p...)
Affinity DataIC50: 62.7nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a white 1536-well microtiter plate (Greiner Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM748860(4,4-difluoro-2-(1-methylpyrazol-4-yl)-N-[4-[3-(2-p...)
Affinity DataIC50: 291nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a white low volume 384-well microtiter plate (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent