BDBM748868 2-(5-cyclopropylisoxazol-3-yl)-N-[4-[3-(2-pyridyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]-2-pyridyl]acetamide::US20250188075, Example 27

SMILES O=C(Cc1cc(C2CC2)on1)Nc1cc(-c2[nH]c3cccnc3c2-c2ccccn2)ccn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 748868   

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM748868(2-(5-cyclopropylisoxazol-3-yl)-N-[4-[3-(2-pyridyl)...)
Affinity DataIC50: 1.57nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a white 1536-well microtiter plate (Greiner Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetCasein kinase I isoform delta(Human)
The Broad Institute

US Patent
LigandPNGBDBM748868(2-(5-cyclopropylisoxazol-3-yl)-N-[4-[3-(2-pyridyl)...)
Affinity DataIC50: 6.38nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a white 1536-well microtiter plate (Greiner Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetCasein kinase I isoform gamma-3(Human)
The Broad Institute

US Patent
LigandPNGBDBM748868(2-(5-cyclopropylisoxazol-3-yl)-N-[4-[3-(2-pyridyl)...)
Affinity DataIC50: 19.7nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a white 1536-well microtiter plate (Greiner Bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetCasein kinase I isoform alpha(Human)
The Broad Institute

US Patent
LigandPNGBDBM748868(2-(5-cyclopropylisoxazol-3-yl)-N-[4-[3-(2-pyridyl)...)
Affinity DataIC50: 244nMAssay Description:For the assay 50 nl of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a white low volume 384-well microtiter plate (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent