BDBM749352 ((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)(2-(3-(trifluoromethyl)pyridin-2-yl)indolizin-1-yl)methanone::US20250188095, Example 11

SMILES Cc6cc(C)nc(N5C[C@@H]4CN(C(=O)c2c(c1ncccc1C(F)(F)F)cn3ccccc23)C[C@@H]4C5)n6

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 749352   

TargetOrexin receptor type 2(Human)
Jiangsu Nhwa Pharmaceutical Co.

US Patent
LigandPNGBDBM749352(((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydro...)
Affinity DataIC50: 200nMAssay Description:(1) Preparation of a reaction buffer (1×Stimulation buffer) required for the experiment: The 5×Stimulation buffer and ddH2O in the Cisbio IP-one kit ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Jiangsu Nhwa Pharmaceutical Co.

US Patent
LigandPNGBDBM749352(((3aR,6aS)-5-(4,6-dimethylpyrimidin-2-yl)hexahydro...)
Affinity DataIC50: 1.00E+3nMAssay Description:(1) Preparation of a reaction buffer (1×Stimulation buffer) required for the experiment: The 5×Stimulation buffer and ddH2O in the Cisbio IP-one kit ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/7/2025
Entry Details
US Patent