BDBM749797 (S)-N-(1-(4-chloro-2-(4-fluorophenyl)-1H-imidazol-5-yl)-7-(oxazol-2-yl)-7-oxoheptyl)thiazole-5-carboxamide::US12331044, Example 88

SMILES O=C(N[C@@H](CCCCCC(=O)C1NC=CO1)C1NC(c2ccc(F)cc2)=NC1Cl)c1cncs1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 749797   

TargetHistone deacetylase 1(Human)TBA
LigandPNGBDBM749797((S)-N-(1-(4-chloro-2-(4-fluorophenyl)-1H-imidazol-...)
Affinity DataIC50: 0.220nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone deacetylase 3(Human)TBA
LigandPNGBDBM749797((S)-N-(1-(4-chloro-2-(4-fluorophenyl)-1H-imidazol-...)
Affinity DataIC50: 0.370nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone deacetylase 2(Human)TBA
LigandPNGBDBM749797((S)-N-(1-(4-chloro-2-(4-fluorophenyl)-1H-imidazol-...)
Affinity DataIC50: 1.40nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM749797((S)-N-(1-(4-chloro-2-(4-fluorophenyl)-1H-imidazol-...)
Affinity DataIC50: 61nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM749797((S)-N-(1-(4-chloro-2-(4-fluorophenyl)-1H-imidazol-...)
Affinity DataIC50: 4.50E+4nMAssay Description:The HDAC 1, 2 assays employed buffer A, which contained 20 mM HEPES, pH 8.0, 1 mM MgCl2, 137 mM NaCl, 2.7 mM KCl, 0.05% BSA. The HDAC3/SMRT assay emp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent