BDBM751158 US20250195521, Example A60

SMILES CCn1c(-c2cccnc2[C@H](C)OC)c2c3cc(ccc31)-c1cccc(c1)C[C@H](NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CCN(C(C)=O)C1)C(=O)N1CCC[C@H](N1)C(=O)OCC(C)(C)C2

InChI Key InChIKey=ZSQTWIYZMUPGOC-UHFFFAOYSA-N

Data  8 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 751158   

TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataKd:  862nMAssay Description:Binding affinity to Cyclophilin A (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetPeptidyl-prolyl cis-trans isomerase A(Human)
Revolution Medicines

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataKd:  897nMAssay Description:Binding affinity to Avi-tagged Cyclophilin A (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGTPase KRas(Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataIC50: 5.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [G12V](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataIC50: 5.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [G12V](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataIC50: 5.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataIC50: 5.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase NRas [G12C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataIC50: 5.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

Targetkras g13d(Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [G13C](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [G12D](Human)
Revolution Medicines

US Patent
LigandChemical structure of BindingDB Monomer ID 751158BDBM751158(US20250195521, Example A60)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent