BDBM751253 1-benzyl-2-(2- chloro-4-(2-(1- methylpyrrolidin-2- yl)ethoxy)phenyl)-5- isopropoxy-1H- benzo[d]imidazole (Isomer 1)::US20250195530, Example A8

SMILES CC(C)Oc1ccc2c(c1)nc(-c1ccc(OCCC3CCCN3C)cc1Cl)n2Cc1ccccc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 751253   

TargetDNA polymerase theta(Human)
Astrazeneca

US Patent
LigandPNGBDBM751253(1-benzyl-2-(2- chloro-4-(2-(1- methylpyrrolidin-2-...)
Affinity DataIC50: 2nMAssay Description:In the assay, Polθ interacts with the substrates (deoxy thymidine triphosphate (dTTP) (Sigma, product code T0251) and a DNA template with a 17-nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent