BDBM751354 (R)-8-(2-chloro- 4-(2-(piperazin-1- yl)ethoxy)phenyl)- 6-(1- methylcyclopropoxy)- 9-(2-phenylpropyl)- 9H-purine::US20250195530, Example J10

SMILES C[C@@H](Cn1c(-c2ccc(OCCN3CCNCC3)cc2Cl)nc2c(OC3(C)CC3)ncnc21)c1ccccc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 751354   

TargetDNA polymerase theta(Human)
Astrazeneca

US Patent
LigandPNGBDBM751354((R)-8-(2-chloro- 4-(2-(piperazin-1- yl)ethoxy)phen...)
Affinity DataIC50: 2nMAssay Description:In the assay, Polθ interacts with the substrates (deoxy thymidine triphosphate (dTTP) (Sigma, product code T0251) and a DNA template with a 17-nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent