BDBM751412 (S)-9-benzyl-8- (2-chloro-4-(2- (2- methylpiperazin- 1-yl) ethoxy)phenyl)- 6-(1-methyl- cyclopropoxy)- 9H-purine::US20250195530, Example R10

SMILES C[C@H]1CNCCN1CCOc1ccc(-c2nc3c(OC4(C)CC4)ncnc3n2Cc2ccccc2)c(Cl)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 751412   

TargetDNA polymerase theta(Human)
Astrazeneca

US Patent
LigandPNGBDBM751412((S)-9-benzyl-8- (2-chloro-4-(2- (2- methylpiperazi...)
Affinity DataIC50: 2nMAssay Description:In the assay, Polθ interacts with the substrates (deoxy thymidine triphosphate (dTTP) (Sigma, product code T0251) and a DNA template with a 17-nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent