BDBM751423 8-(4-(2-((1R,4R)- 2,5- diazabicyclo [2.2.1]heptan-2- yl)ethoxy)-2- chlorophenyl)-9- benzyl-6-(1- methylcyclo- propoxy)- 9H-purine::US20250195530, Example R20

SMILES CC1(Oc2ncnc3c2nc(-c2ccc(OCCN4C[C@H]5C[C@@H]4CN5)cc2Cl)n3Cc2ccccc2)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 751423   

TargetDNA polymerase theta(Human)
Astrazeneca

US Patent
LigandPNGBDBM751423(8-(4-(2-((1R,4R)- 2,5- diazabicyclo [2.2.1]heptan-...)
Affinity DataIC50: 2nMAssay Description:In the assay, Polθ interacts with the substrates (deoxy thymidine triphosphate (dTTP) (Sigma, product code T0251) and a DNA template with a 17-nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent