BDBM751427 (S)-9-benzyl-8- (2-chloro-4-(2- (3- methylpiperazin- 1-yl) ethoxy)phenyl)- 6-(1-methyl- cyclopropoxy)- 9H-purine::US20250195530, Example R3

SMILES C[C@H]1CN(CCOc2ccc(-c3nc4c(OC5(C)CC5)ncnc4n3Cc3ccccc3)c(Cl)c2)CCN1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 751427   

TargetDNA polymerase theta(Human)
Astrazeneca

US Patent
LigandPNGBDBM751427((S)-9-benzyl-8- (2-chloro-4-(2- (3- methylpiperazi...)
Affinity DataIC50: 2.51nMAssay Description:In the assay, Polθ interacts with the substrates (deoxy thymidine triphosphate (dTTP) (Sigma, product code T0251) and a DNA template with a 17-nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent