BDBM751436 8-(2-chloro-4-(2- (piperazin-1- yl)ethoxy)phenyl)- 9-((4-cyclo- propylpyridin- 2-yl)methyl)-6- (1-methyl- cyclopropoxy)- 9H-purine::US20250195530, Example S3

SMILES CC1(Oc2ncnc3c2nc(-c2ccc(OCCN4CCNCC4)cc2Cl)n3Cc2cc(C3CC3)ccn2)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 751436   

TargetDNA polymerase theta(Human)
Astrazeneca

US Patent
LigandPNGBDBM751436(8-(2-chloro-4-(2- (piperazin-1- yl)ethoxy)phenyl)-...)
Affinity DataIC50: 2nMAssay Description:In the assay, Polθ interacts with the substrates (deoxy thymidine triphosphate (dTTP) (Sigma, product code T0251) and a DNA template with a 17-nucleo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent