BDBM752585 3-isopropyl-1,8-dimethyl-5-[[(1R)- 1-[3- (trifluoromethyl)phenyl]ethyl] amino]imidazo[4,5-g]phthalazin-2-one::US20250197407, Compound 12

SMILES Cc2nnc(N[C@H](C)c1cccc(C(F)(F)F)c1)c3cc4c(cc23)n(C)c(=O)n4C(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752585   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752585(3-isopropyl-1,8-dimethyl-5-[[(1R)- 1-[3- (trifluor...)
Affinity DataIC50: 8.13nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent