BDBM752625 1,3,8-trimethyl-5-[[(1R)-1-[2- methyl-3- (trifluoromethyl)phenyl]ethyl]amino] imidazo[4,5-g]phthalazin-2-one::US20250197407, Compound 54

SMILES Cc1c([C@@H](C)Nc2nnc(C)c3cc4c(cc23)n(C)c(=O)n4C)cccc1C(F)(F)F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752625   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752625(1,3,8-trimethyl-5-[[(1R)-1-[2- methyl-3- (trifluor...)
Affinity DataIC50: 6.17nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent