BDBM752649 1-isopropyl-3,3,5-trimethyl-8- [[(1R)-1-[3-(1,1-difluoro-2- hydroxy-ethyl)-2-methyl- phenyl]ethyl]amino]pyrrolo[2,3- g]phthalazin-2-one::US20250197407, Compound 79

SMILES Cc1c([C@@H](C)Nc2nnc(C)c3cc4c(cc23)N(C(C)C)C(=O)C4(C)C)cccc1C(F)(F)CO

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752649   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752649(1-isopropyl-3,3,5-trimethyl-8- [[(1R)-1-[3-(1,1-di...)
Affinity DataIC50: 6.76nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent