BDBM752655 3-isopropyl-1,8-dimethyl-5-[[(1R)- 1-[3-(1,1-difluoro-2-hydroxy- ethyl)-2-methyl- phenyl]ethyl]amino]imidazo[4,5- g]phthalazin-2-one::US20250197407, Compound 85

SMILES Cc1c([C@@H](C)Nc2nnc(C)c3cc4c(cc23)n(C(C)C)c(=O)n4C)cccc1C(F)(F)CO

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752655   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752655(3-isopropyl-1,8-dimethyl-5-[[(1R)- 1-[3-(1,1-diflu...)
Affinity DataIC50: 8.32nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent