BDBM752657 3-isopropyl-1,8-dimethyl-5-[[(1R)- 1-[3-(1,1-difluoro-2-hydroxy-2- methyl- propyl)phenyl]ethyl]amino]imidazo [4,5-g]phthalazin-2-one::US20250197407, Compound 87

SMILES Cc1nnc(N[C@H](C)c2cccc(C(F)(F)C(C)(C)O)c2)c2cc3c(cc12)n(C)c(=O)n3C(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752657   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752657(3-isopropyl-1,8-dimethyl-5-[[(1R)- 1-[3-(1,1-diflu...)
Affinity DataIC50: 8.51nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent