BDBM752658 1,5-dimethyl-8-[[(1R)-1-[3-(1,1- difluoro-2-hydroxy- ethyl)phenyl]ethyl]amino]spiro [pyrrolo[2,3-g]phthalazine-3,4''- tetrahydropyran]-2-one::US20250197407, Compound 88

SMILES Cc1nnc(N[C@H](C)c2cccc(C(F)(F)CO)c2)c2cc3c(cc12)C1(CCOCC1)C(=O)N3C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752658   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752658(1,5-dimethyl-8-[[(1R)-1-[3-(1,1- difluoro-2-hydrox...)
Affinity DataIC50: 7.76nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent