BDBM752672 3-methoxy-1,3,5-trimethyl-8- [[(1R)-1-[3-(1,1-difluoro-2- hydroxy-2-methyl-propyl)-2- methyl- phenyl]ethyl]amino]pyrrolo[2,3- g]phthalazin-2-one::US20250197407, Compound 102

SMILES COC1(C)C(=O)N(C)c2cc3c(N[C@H](C)c4cccc(C(F)(F)C(C)(C)O)c4C)nnc(C)c3cc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752672   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752672(3-methoxy-1,3,5-trimethyl-8- [[(1R)-1-[3-(1,1-difl...)
Affinity DataIC50: 8.32nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent