BDBM752681 1-isopropyl-3,3,5-trimethyl-8- [[(1R)-1-[3-(1,1-difluoro-2- hydroxy-2-methyl-propyl)-2- fluoro- phenyl]ethyl]amino]pyrrolo[2,3- g]phthalazin-2-one::US20250197407, Compound 111

SMILES Cc1nnc(N[C@H](C)c2cccc(C(F)(F)C(C)(C)O)c2F)c2cc3c(cc12)C(C)(C)C(=O)N3C(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752681   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752681(1-isopropyl-3,3,5-trimethyl-8- [[(1R)-1-[3-(1,1-di...)
Affinity DataIC50: 7.41nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent