BDBM752689 1-cyclopropyl-5-methyl-8-[[(1R)- 1-[3-(1,1-difluoro-2-hydroxy- ethyl)-2-methyl- phenyl]ethyl]amino]spiro[pyrrolo [2,3-g]phthalazine-3,4''- tetrahydropyran]-2-one::US20250197407, Compound 119

SMILES Cc1c([C@@H](C)Nc2nnc(C)c3cc4c(cc23)N(C2CC2)C(=O)C42CCOCC2)cccc1C(F)(F)CO

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752689   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752689(1-cyclopropyl-5-methyl-8-[[(1R)- 1-[3-(1,1-difluor...)
Affinity DataIC50: 7.41nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent