BDBM752708 1-cyclopropyl-8-[[(1R)-1-[3-(1,1- difluoro-2-hydroxy-ethyl)-2- fluoro-phenyl]ethyl]amino]-3- (methoxymethyl)-3,5-dimethyl- pyrrolo[3,2-g]phthalazin-2-one::US20250197407, Compound 138

SMILES COCC1(C)C(=O)N(C2CC2)c2cc3c(N[C@H](C)c4cccc(C(F)(F)CO)c4F)nnc(C)c3cc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752708   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752708(1-cyclopropyl-8-[[(1R)-1-[3-(1,1- difluoro-2-hydro...)
Affinity DataIC50: 6.61nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent