BDBM752777 3-ethyl-3-methoxy-1,5-dimethyl- 8-[[(1R)-1-[3-(1,1-difluoro-2- hydroxy-ethyl)-2-fluoro- phenyl]ethyl]amino]pyrrolo[2,3- g]phthalazin-2-one::US20250197407, Compound 207

SMILES CCC1(OC)C(=O)N(C)c2cc3c(N[C@H](C)c4cccc(C(F)(F)CO)c4F)nnc(C)c3cc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 752777   

TargetKRas/Son of Sevenless Homolog 1(Human)
Jazz Pharmaceuticals Ireland

US Patent
LigandPNGBDBM752777(3-ethyl-3-methoxy-1,5-dimethyl- 8-[[(1R)-1-[3-(1,1...)
Affinity DataIC50: 8.51nMAssay Description:The capacity of compounds to inhibit SOS1 binding to KRAS-WT (wild-type) was quantified using a FRET-based protein-protein interaction assay. The ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent