BDBM752783 US20250197424, Compound 1a

SMILES F[C@H]1CN2CCC[C@@]2(COc2nc3c(c(N4CC5CCC(C5)C4)n2)CCC2(CCc4c(Cl)cccc42)C3)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 752783   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Shanghai Pharmaceuticals Holding Co.

US Patent
LigandPNGBDBM752783(US20250197424, Compound 1a)
Affinity DataIC50: 45.6nMAssay Description:a) BI-2852 was used as a positive control, with its stock solution as the first dilution point, followed by a 3-fold dilution, making a total of 10+0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Shanghai Pharmaceuticals Holding Co.

US Patent
LigandPNGBDBM752783(US20250197424, Compound 1a)
Affinity DataIC50: 333nMAssay Description:a) BI-2852 was used as a positive control, with its stock solution as the first dilution point, followed by a 3-fold dilution, making a total of 10+0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Shanghai Pharmaceuticals Holding Co.

US Patent
LigandPNGBDBM752783(US20250197424, Compound 1a)
Affinity DataIC50: 4.10E+3nMAssay Description:a) BI-2852 was used as a positive control, with its stock solution as the first dilution point, followed by a 3-fold dilution, making a total of 10+0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent