BDBM752790 US20250197424, Compound 7a

SMILES C[C@H]1CC2(CCc3c(nc(OC[C@@]45CCCN4C[C@H](F)C5)nc3N3CC4CCC(C4)C3)C2)c2cc(O)cc(Cl)c21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 752790   

TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Shanghai Pharmaceuticals Holding Co.

US Patent
LigandPNGBDBM752790(US20250197424, Compound 7a)
Affinity DataIC50: 21.5nMAssay Description:a) BI-2852 was used as a positive control, with its stock solution as the first dilution point, followed by a 3-fold dilution, making a total of 10+0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetGTPase KRas [G12D]/RAF proto-oncogene serine/threonine-protein kinase(Human)
Shanghai Pharmaceuticals Holding Co.

US Patent
LigandPNGBDBM752790(US20250197424, Compound 7a)
Affinity DataIC50: 24nMAssay Description:a) BI-2852 was used as a positive control, with its stock solution as the first dilution point, followed by a 3-fold dilution, making a total of 10+0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Shanghai Pharmaceuticals Holding Co.

US Patent
LigandPNGBDBM752790(US20250197424, Compound 7a)
Affinity DataIC50: 246nMAssay Description:a) BI-2852 was used as a positive control, with its stock solution as the first dilution point, followed by a 3-fold dilution, making a total of 10+0...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent