BDBM752874 (S)-3-((9-ethyl-2-(((2R*,3S*)-4,4,4-trifluoro-3-hydroxybutan-2-yl)amino)-9H-purin-6-yl)amino)-N-methylpyrrolidine-1-sulfonamide::US20250197425, Example 50

SMILES CCn3cnc2c(N[C@H]1CCN(S(=O)(=O)NC)C1)nc(N[C@@H](C)[C@H](O)C(F)(F)F)nc23

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 752874   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-D1(Human)
Astrazeneca

US Patent
LigandPNGBDBM752874((S)-3-((9-ethyl-2-(((2R*,3S*)-4,4,4-trifluoro-3-hy...)
Affinity DataIC50: 64nMAssay Description:Compounds were tested in breast cancer cell line MCF-7 to assess inhibition of CDK1, CDK2, and CDK4 activity. MCF-7 cells transiently transfected wit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/15/2025
Entry Details
US Patent

LigandPNGBDBM752874((S)-3-((9-ethyl-2-(((2R*,3S*)-4,4,4-trifluoro-3-hy...)
Affinity DataIC50: 2.35E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/15/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Astrazeneca

US Patent
LigandPNGBDBM752874((S)-3-((9-ethyl-2-(((2R*,3S*)-4,4,4-trifluoro-3-hy...)
Affinity DataIC50: 1.42E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/15/2025
Entry Details
US Patent