BDBM754841 1-(2-cyano-4-methyl- phenyl)-N-(2,3,6- trifluoro-4-(2-(((3S,5S)- 5-fluoropiperidin-3-yl)- amino)-8-isopropyl-7- oxo-7,8-dihydropyrido- [2,3-d)pyrimidin-6-yl)- phenyl)methanesulfon- amide::US12344603, Compound 107

SMILES Cc1ccc(CS(=O)(=O)Nc2c(F)cc(-c3cc4cnc(N[C@@H]5CNC[C@@H](F)C5)nc4n(C(C)C)c3=O)c(F)c2F)c(C#N)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 754841   

LigandPNGBDBM754841(1-(2-cyano-4-methyl- phenyl)-N-(2,3,6- trifluoro-4...)
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
10/22/2025
Entry Details
US Patent