BDBM754846 N-(2-fluoro-4-(2- (((3S,5S)-5-fluoropiper- idin-3-yl)amino)-8-iso- propyl-7-oxo-7,8- dihydropyrido[2,3-d]- pyrimidin-6-yl)phenyl)- 1-(4-fluorophenyl)- methanesulfonamide hydrochloride::US12344603, Compound 112

SMILES CC(C)n1c(=O)c(-c2ccc(NS(=O)(=O)Cc3ccc(F)cc3)c(F)c2)cc2cnc(N[C@@H]3CNC[C@@H](F)C3)nc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 754846   

LigandPNGBDBM754846(N-(2-fluoro-4-(2- (((3S,5S)-5-fluoropiper- idin-3-...)
Affinity DataIC50: 0.130nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
10/22/2025
Entry Details
US Patent