BDBM754849 1-cyclohexyl-N-(4-(2- (((1r,4r)-4-(dimethyl- amino)cyclohexyl)- amino)-8-isopropyl-7- oxo-7,8-dihydropyrido- [2,3-d]pyrimidin-6- yl)-2-fluorophenyl)- methanesulfonamide::US12344603, Compound 115

SMILES CC(C)n1c(=O)c(-c2ccc(NS(=O)(=O)CC3CCCCC3)c(F)c2)cc2cnc(N[C@H]3CC[C@H](N(C)C)CC3)nc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 754849   

LigandPNGBDBM754849(1-cyclohexyl-N-(4-(2- (((1r,4r)-4-(dimethyl- amino...)
Affinity DataIC50: 0.150nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent