BDBM754851 N-(4-(2-(((1r,4r)-4- (dimethylamino)cyclo- hexyl)amino)-8- isopropyl-7-oxo-7,8- dihydropyrido[2,3-d]- pyrimidin-6-yl)-2,6- difluorophenyl)-1- phenylmethanesulfon- amide::US12344603, Compound 117

SMILES CC(C)n1c(=O)c(-c2cc(F)c(NS(=O)(=O)Cc3ccccc3)c(F)c2)cc2cnc(N[C@H]3CC[C@H](N(C)C)CC3)nc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 754851   

LigandPNGBDBM754851(N-(4-(2-(((1r,4r)-4- (dimethylamino)cyclo- hexyl)a...)
Affinity DataIC50: 0.180nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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Date in BDB:
10/22/2025
Entry Details
US Patent