BDBM754973 N-[4-[2-[[4-(dimethyl- amino)cyclohexyl]- amino]-8-isopropyl-7- oxo-pteridin-6-yl]-2,6- difluoro-phenyl]pro- pane-1-sulfonamide::US12344603, Compound 242

SMILES CCCS(=O)(=O)Nc1c(F)cc(-c2nc3cnc(N[C@H]4CC[C@H](N(C)C)CC4)nc3n(C(C)C)c2=O)cc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 754973   

LigandPNGBDBM754973(N-[4-[2-[[4-(dimethyl- amino)cyclohexyl]- amino]-8...)
Affinity DataIC50: 0.100nMAssay Description:A His-tagged IRE1α kinase dead construct containing the kinase and RNase domains (KR, AA G547-L977, D688N) was expressed in Sf9 insect cells. The pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent