BDBM755029 8-chloro-7-(2-fluoro-5-hydroxy-phenyl)-9-(trifluoromethyl)-5H-pyrimido[1,2-a][1,4]benzodiazepin-3-one::US12344614, Example 11

SMILES O=c1ccn2c(n1)CN=C(c1cc(O)ccc1F)c1c-2ccc(C(F)(F)F)c1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 755029   

LigandPNGBDBM755029(8-chloro-7-(2-fluoro-5-hydroxy-phenyl)-9-(trifluor...)
Affinity DataKi:  1.54nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM755029(8-chloro-7-(2-fluoro-5-hydroxy-phenyl)-9-(trifluor...)
Affinity DataKi:  1.88nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM755029(8-chloro-7-(2-fluoro-5-hydroxy-phenyl)-9-(trifluor...)
Affinity DataKi:  5.17nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM755029(8-chloro-7-(2-fluoro-5-hydroxy-phenyl)-9-(trifluor...)
Affinity DataKi:  359nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 at a conce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent