BDBM755067 Synthesis of (7R,E)-7-(Hydroxymethyl)-31-methyl-18-(methylamino)-31H-5-oxa-2,8-diaza-1(6,3),3(4,6)-diimidazo[1,2-b]pyridazinacyclononaphan-9-one ::US20250213571, Compound 2

SMILES CNc1cc2nn3c(cnc13)C(=O)N[C@H](CO)COCc1cc(c3nnn(C)c3c1)N2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 755067   

LigandPNGBDBM755067(Synthesis of (7R,E)-7-(Hydroxymethyl)-31-methyl-18...)
Affinity DataKd: <10nMAssay Description:Binding constants for the compounds described herein against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Discov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Alumis

US Patent
LigandPNGBDBM755067(Synthesis of (7R,E)-7-(Hydroxymethyl)-31-methyl-18...)
Affinity DataKd:  505nMAssay Description:Binding constants for the compounds described herein against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Discov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM755067(Synthesis of (7R,E)-7-(Hydroxymethyl)-31-methyl-18...)
Affinity DataKd: <3.00E+4nMAssay Description:Binding constants for the compounds described herein against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Discov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent