BDBM755070 Synthesis of (R,13E,14E)-31,7-dimethyl-17-(methylamino)-31H-5,8-dioxa-2-aza-1(5,3),3(4,6)-dipyrazolo [1,5-a]pyrimidinacyclononaphan-9-one ::US20250213571, Compound 4

SMILES CNc1cc2nc3c(cnn13)C(=O)O[C@H](C)COCc1cc(c3nnn(C)c3c1)N2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 755070   

LigandPNGBDBM755070(Synthesis of (R,13E,14E)-31,7-dimethyl-17-(methyla...)
Affinity DataKd: <10nMAssay Description:Binding constants for the compounds described herein against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Discov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Alumis

US Patent
LigandPNGBDBM755070(Synthesis of (R,13E,14E)-31,7-dimethyl-17-(methyla...)
Affinity DataKd:  5.50E+3nMAssay Description:Binding constants for the compounds described herein against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Discov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

LigandPNGBDBM755070(Synthesis of (R,13E,14E)-31,7-dimethyl-17-(methyla...)
Affinity DataKd: <3.00E+4nMAssay Description:Binding constants for the compounds described herein against the JH2 domain were determined by the following protocol for a KINOMEscan® assay (Discov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent