BDBM755399 US20250214932, Example 29

SMILES CC1(NC(=O)CN2CC3(CCC(C(=O)Nc4cc(F)cc(C(F)F)c4)CC3)C2)CCC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 755399   

TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Praxis Precision Medicines

US Patent
LigandPNGBDBM755399(US20250214932, Example 29)
Affinity DataIC50: 102nMAssay Description:The compound plate was created at 2× concentrated in the extracellular solution. The compound was diluted to 1:2 when added to the recording well. Th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Human)
Praxis Precision Medicines

US Patent
LigandPNGBDBM755399(US20250214932, Example 29)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of the T-type voltage gated calcium channel (Cav3.1) was evaluated using a HEK-293 natClytin/TASK1+Cav3.1 cell line. Currents were recorde...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent