BDBM756246 (E)-3-(4-(4-(7-((3,5- dimethoxyphenyl)amino)- quinoxalin-2-yl)-1H- pyrazol-1-yl)piperidine-1- carbonyl)-1-(4-(dimethyl- amino)but-2-enoyl)- azetidine-3-carbonitrile::US12351571, Example 11

SMILES N#CC1(C(=O)N2CCC(n3cc(-c4cnc5ccc(Nc6cc(OC)cc(OC)c6)cc5n4)cn3)CC2)CN(C(=O)/C=C/CN(C)C)C1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 756246   

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM756246((E)-3-(4-(4-(7-((3,5- dimethoxyphenyl)amino)- quin...)
Affinity DataIC50: 3nMAssay Description:Table EA: The potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM756246((E)-3-(4-(4-(7-((3,5- dimethoxyphenyl)amino)- quin...)
Affinity DataIC50: 7nMAssay Description:Table EB: FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phospho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM756246((E)-3-(4-(4-(7-((3,5- dimethoxyphenyl)amino)- quin...)
Affinity DataIC50: 15nMAssay Description:Table EB: FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phospho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM756246((E)-3-(4-(4-(7-((3,5- dimethoxyphenyl)amino)- quin...)
Affinity DataIC50: 44nMAssay Description:Table EA: The potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM756246((E)-3-(4-(4-(7-((3,5- dimethoxyphenyl)amino)- quin...)
Affinity DataIC50: 44nMAssay Description:Table EB: FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phospho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent