BDBM756254 (R,E)-1-(3-(3-(4-(7-((3,5- dimethoxyphenyl)amino)- quinoxalin-2-yl)-1H- pyrazol-1-yl)pyrrolidine- 1-carbonyl)-3-fluoro- azetidin-1-yl)-4-(dimethyl- amino)but-2-en-1-one::US12351571, Example 19

SMILES COc1cc(Nc2ccc3ncc(-c4cnn([C@@H]5CCN(C(=O)C6(F)CN(C(=O)/C=C/CN(C)C)C6)C5)c4)nc3c2)cc(OC)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 756254   

LigandPNGBDBM756254((R,E)-1-(3-(3-(4-(7-((3,5- dimethoxyphenyl)amino)-...)
Affinity DataIC50: 4nMAssay Description:Table EA: The potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM756254((R,E)-1-(3-(3-(4-(7-((3,5- dimethoxyphenyl)amino)-...)
Affinity DataIC50: 50nMAssay Description:Table EB: FGFR3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phospho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM756254((R,E)-1-(3-(3-(4-(7-((3,5- dimethoxyphenyl)amino)-...)
Affinity DataIC50: 55nMAssay Description:Table EA: The potency of compounds inhibiting human isoforms of FGFR kinase was determined using Life Technologies' Homogeneous Time Resolved Flu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM756254((R,E)-1-(3-(3-(4-(7-((3,5- dimethoxyphenyl)amino)-...)
Affinity DataIC50: 166nMAssay Description:Table EB: FGFR2 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phospho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM756254((R,E)-1-(3-(3-(4-(7-((3,5- dimethoxyphenyl)amino)-...)
Affinity DataIC50: 288nMAssay Description:Table EB: FGFR1 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phospho...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
US Patent