BDBM756377 US12351572, Example 159

SMILES CC(C)(O)c1ccc(Nc2cc(Nc3ncccc3S(C)(=O)=O)c(C(=O)C3CC3)cn2)nc1F

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 756377   

LigandPNGBDBM756377(US12351572, Example 159)
Affinity DataKd: <1nMAssay Description:Streptavidin-coated magnetic beads were treated with biotinylated small molecule ligands for 30 minutes at room temperature to generate affinity resi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [583-855](Human)
Alumis

US Patent
LigandPNGBDBM756377(US12351572, Example 159)
Affinity DataKd: <100nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [866-1054](Human)
Alumis

US Patent
LigandPNGBDBM756377(US12351572, Example 159)
Affinity DataKd:  5.50E+3nMAssay Description:Similar to the method for TYK2 JH2 binding described above, JAK1 JH2 and JAK2 JH1 domain binding assay was performed using DiscoverX's KINOMEscan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/23/2025
Entry Details
US Patent