BDBM756588 7-((4-(2-methyl-6-(methylcarbamoyl)pyridin-3-yl)piperazin-1-yl)methyl)-3-methylisoxazolo[4,5-c]quinolin-4(5H)-one::US20250215013, Example 47

SMILES CNC(=O)c1ccc(N2CCN(Cc3ccc4c(c3)[nH]c(=O)c3c(C)noc34)CC2)c(C)n1

InChI Key InChIKey=VGOGMUIBXGGDAR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 756588   

TargetPoly [ADP-ribose] polymerase 1(Human)
Impact Therapeutics (Shanghai)

US Patent
LigandChemical structure of BindingDB Monomer ID 756588BDBM756588(7-((4-(2-methyl-6-(methylcarbamoyl)pyridin-3-yl)pi...)
Affinity DataIC50: 0.860nMAssay Description:The solution of recombinant poly(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) (40 ng enzyme/well) and the compounds to be tested were mixed, resp...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent

TargetProtein cereblon/PARP2(Human)
Impact Therapeutics (Shanghai)

US Patent
LigandChemical structure of BindingDB Monomer ID 756588BDBM756588(7-((4-(2-methyl-6-(methylcarbamoyl)pyridin-3-yl)pi...)
Affinity DataIC50: 504nMAssay Description:The solution of recombinant poly(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) (40 ng enzyme/well) and the compounds to be tested were mixed, resp...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/26/2025
Entry Details
US Patent