BDBM757304 (S)-C16-(1,1-dioxidoisothiazolidin-2-yl)-C32-deoxo-rapamycin::US20250223297, Example 1

SMILES C=C1[C@H](C)C[C@H](C)/C=C\C=C/C=C(/C)C(N2CCCS2(=O)=O)C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC[C@H](C)/C=C(/C)[C@@H](O)[C@H]1OC

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 757304   

TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Human)
Novartis

US Patent
LigandPNGBDBM757304((S)-C16-(1,1-dioxidoisothiazolidin-2-yl)-C32-deoxo...)
Affinity DataKd:  0.350nMAssay Description:N-terminal avi-his6 tagged FKBP fusions to FKBP12, FKBP51 and FKBP52 were expressed in E. coli and purified using standard chromatography. Each prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/27/2025
Entry Details
US Patent

TargetPeptidyl-prolyl cis-trans isomerase FKBP5(Human)
Novartis

US Patent
LigandPNGBDBM757304((S)-C16-(1,1-dioxidoisothiazolidin-2-yl)-C32-deoxo...)
Affinity DataKd:  153nMAssay Description:N-terminal avi-his6 tagged FKBP fusions to FKBP12, FKBP51 and FKBP52 were expressed in E. coli and purified using standard chromatography. Each prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/27/2025
Entry Details
US Patent

TargetPeptidyl-prolyl cis-trans isomerase FKBP4(Human)
Novartis

US Patent
LigandPNGBDBM757304((S)-C16-(1,1-dioxidoisothiazolidin-2-yl)-C32-deoxo...)
Affinity DataKd:  174nMAssay Description:N-terminal avi-his6 tagged FKBP fusions to FKBP12, FKBP51 and FKBP52 were expressed in E. coli and purified using standard chromatography. Each prote...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/27/2025
Entry Details
US Patent