BDBM757719 6-((2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)(methyl)amino)ethyl)(methyl)amino)-N-hydroxynicotinamide ::US12358911, Compound 3

SMILES CC(=O)c1c(C)c2cnc(Nc3ccc(N(C)CCN(C)c4ccc(C(=O)NO)cn4)cn3)nc2n(C2CCCC2)c1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 757719   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757719(6-((2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-...)
Affinity DataIC50: 17.5nMAssay Description:Method 1: In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757719(6-((2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-...)
Affinity DataIC50: 37.5nMAssay Description:Method 1: In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757719(6-((2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-...)
Affinity DataIC50: 62.5nMAssay Description:The inhibitory effect of compounds on HDAC-1 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757719(6-((2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-...)
Affinity DataIC50: 87.5nMAssay Description:The inhibitory effect of compounds on HDAC-1 and HDAC-6 function was determined in vitro using an optimized homogenous assay performed in 384-well pl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Hangzhou Innogate Pharma

US Patent
LigandPNGBDBM757719(6-((2-((6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-...)
Affinity DataIC50: 2.00E+3nMAssay Description:Method 1: In vitro enzymatic activity of the CDK isoforms CDK2/CycA2, CDK4/CycD3 and CDK6/cycD3 were measured using Mobility Shift Assay that monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/29/2025
Entry Details
US Patent