BDBM757863 2-(3-(1,1-difluoro-2-(4-methyl-4H-1,2,4- triazol-3-yl)ethyl)phenyl)-4- (trifluoromethyl)isoindolin-1-one::US20250230147, Compound 15

SMILES Cn1cnnc1CC(F)(F)c1cccc(N2Cc3c(cccc3C(F)(F)F)C2=O)c1

InChI Key InChIKey=MNDDUCWFPGFVDI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 757863   

TargetE3 ubiquitin-protein ligase CBL-B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757863BDBM757863(2-(3-(1,1-difluoro-2-(4-methyl-4H-1,2,4- triazol-3...)
Affinity DataIC50: 3.50E+3nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase CBL-C(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 757863BDBM757863(2-(3-(1,1-difluoro-2-(4-methyl-4H-1,2,4- triazol-3...)
Affinity DataIC50: 6.40E+3nMAssay Description:Affinity of binding to Cbl-b and c-Cbl for compounds described herein can be assessed by surface plasmon resonance (SPR) according to the following p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/30/2025
Entry Details
US Patent